Processing of derived forms in high-functioning dyslexics   总被引：1，自引：0，他引：1  

Deacon SH  Parrila R  Kirby JR 《Annals of dyslexia》2006,56(1):103-128

We report on an experiment designed to evaluate processing of derived forms in high-functioning dyslexics, defined as university students with a history of reading difficulties who have age-appropriate reading comprehension skills. We compared high-functioning dyslexics with a group of normal adult readers in their performance on a lexical decision task with derived items (such as cloudy and ably) and pseudo-derived items (such as belly and gravy). Some items contained an orthographic change (such as able-ably and gravy) and others did not (such as cloud - cloudy). The results indicated that although control participants’ response times varied systematically as a function of morphological complexity, those of high-functioning dyslexics did not. Further, there was some evidence of a relationship between derivational processing and reading. It seems that high-functioning dyslexics have persistent difficulties in processing one particular aspect of morphology; that of derived forms.  相似文献   

Conditioning of tentacle lowering in the snail (Helix aspersa): Acquisition, latent inhibition, overshadowing, second-order conditioning, and sensory preconditioning     

Loy I  Fernández V  Acebes F 《Learning & behavior》2006,34(3):305-314

In a series of related experiments, we studied associative phenomena in snails (Helix aspersa), using the conditioning procedure of tentacle lowering. Experiments 1A and 1B demonstrated a basic conditioning effect in which the pairing of an odor (apple) as the conditioned stimulus (CS) with the opportunity to feed on carrot as the unconditioned stimulus (US) made snails exhibit increased levels of tentacle lowering in the presence of the CS. Experiments 2 and 3 showed that the magnitude of the conditioning was reduced when snails were exposed to the CS prior to the conditioning trial (a latent inhibition effect). Experiment 4 examined the effects produced by pairing a compound CS (apple—pear) with food presentations and demonstrated the existence of an overshadowing effect between the two odors. Experiment 5 revealed that pairing one CS with another previously conditioned stimulus increased tentacle lowering to the new CS (a second-order conditioning effect). Finally, Experiment 6 showed that pairing two odors prior to conditioning of one of them promoted an increase in tentacle lowering in response to the other (a sensory preconditioning effect). The results are discussed in terms of an associative analysis of conditioning and its implications for the study of cognition in invertebrates.  相似文献   

Serial position effects in social transmission of food preference     

Juárez-Maldonado CE  Ortega-Saavedra G  Huichan-Olivares F  Gómez-Romero J  Cruz-Morales SE  Arriaga-Ramírez JC 《Learning & behavior》2006,34(4):374-378

The serial position effect in Long-Evans rats was evaluated in two experiments. In Experiment 1, the effect in a group for which an interstimulus interval (ISI) was introduced between items in a list of demonstrators was compared with that in a group without an ISI. With an ISI, a recency effect was produced. In Experiment 2, a serial position effect group was compared with four groups in which either the distinctiveness or the context of the middle item was changed, relative to the items on either side of it. A von Restorff effect was produced when a rat from a different strain was used as a demonstrator in Position 2. The results for Experiment 1 are discussed in relation to interstimulus effects in monkeys and those for Experiment 2 with respect to changes in the physical properties of middle items.  相似文献   

Nutritional evaluation of caseins and whey proteins and their hydrolysates from Protamex   总被引：4，自引：0，他引：4  

夏文水 《Journal of Zhejiang University. Science. B》2006,7(2):90-98

Whey protein concentrate （WPC 80） and sodium caseinate were hydrolyzed by Protamex to 5%, 10%, 15%, and 20% degree of hydrolysis （DH）. WPC 80, sodium caseinate and their hydrolysates were then analyzed, compared and evaluated for their nutritional qualities. Their chemical composition, protein solubility, amino acid composition, essential amino acid index （EAA index）, biological value （BV）, nutritional index （NI）, chemical score, enzymic protein efficiency ratio （E-PER） and in vitro protein digestibility （IVPD） were determined. The results indicated that the enzymatic hydrolysis of WPC 80 and sodium caseinate by Protamex improved the solubility and IVPD of their hydrolysates. WPC 80, sodium caseinate and their hydrolysates were high-quality proteins and had a surplus of essential amino acids compared with the FAO/WHO/UNU （1985） reference standard. The nutritive value of WPC 80 and its hydrolysates was superior to that of sodium caseinate and its hydrolysates as indicated by some nutritional parameters such as the amino acid composition, chemical score, EAA index and predicted BV. However, the E-PER was lower for the WPC hydrolysates as compared to unhydrolyzed WPC 80 but sodium caseinate and its hydrolysates did not differ significantly. The nutritional qualities of WPC 80, sodium caseinate and their hydrolysates were good and make them appropriate for food formulations or as nutritional supplements.  相似文献   

Question-answering systems as efficient sources of terminological information: an evaluation     

Olvera-Lobo MD  Gutiérrez-Artacho J 《Health information and libraries journal》2010,27(4):268-276

Background: Question‐answering systems (or QA Systems) stand as a new alternative for Information Retrieval Systems. Most users frequently need to retrieve specific information about a factual question to obtain a whole document. Objectives: The study evaluates the efficiency of QA systems as terminological sources for physicians, specialised translators and users in general. It assesses the performance of one open‐domain QA system, START, and one restricted‐domain QA system, MedQA. Method: The study collected two hundred definitional questions (What is…?), either general or specialised, from the health website WebMD. Sources used by the open‐domain QA system, START, and the restricted‐domain QA system, MedQA, were studied to retrieve answers, and later a range of evaluation measures (precision, Mean Reciprocal Rank, Total Reciprocal Rank, First Hit Success) were applied to mark the quality of answers. Results: It was established that both systems are useful in the retrieval of valid definitional healthcare information, with an acceptable degree of coherent and precise responses from both. The answers supplied by MedQA were more reliable that those of START in the sense that they came from specialised clinical or academic sources, most of them showing links to further research articles. Conclusions: Results obtained show the potential of this type of tool in the more general realm of information access, and the retrieval of health information. They may be considered a good, reliable and reasonably precise alternative in alleviating the information overload. Both QA systems can help professionals and users can obtain healthcare information.  相似文献   

Serum thyroglobulin antibody levels within or near to the reference range may interfere with thyroglobulin measurement     

Zoltán L?csei  István Szabolcs  Károly Rácz  Gábor L. Kovács  Dóra Horváth  Erzsébet Toldy 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(3):365-370

High concentration of thyroglobulin antibodies (TgAb) is a major limiting factor of thyroglobulin measurements in patients with differentiated thyroid cancer. We investigated whether thyroglobulin antibody added to serum samples could interfere with the thyroglobulin assay. Thyroglobulin levels in serum samples with different concentrations of thyroglobulin were measured by electrochemiluminescence immunoassay before and after the addition of increasing concentrations of thyroglobulin antibody using the secondary calibrator solution of the thyroglobulin assay kit containing sheep thyroglobulin antibody to reach thyroglobulin antibody levels within or near to the reference range. Thyroglobulin and thyroglobulin antibody concentrations were also measured in 134 serum samples from 27 patients after thyroid ablation. There was a strong negative association (slope = −1.179) between thyroglobulin antibody and thyroglobulin concentrations in samples with added thyroglobulin antibody (beta = −0.86; P < 0.001). Changes in thyroglobulin concentrations were described mathematically as loss of thyroglobulin% = −0.2408 × Ln(thyroglobulin antibody IU/ml) + 0.1944. Thyroglobulin concentrations were significantly lower than those calculated from experiments with added thyroglobulin antibody in 26/134 samples from patients after thyroid ablation. We conclude that if the same TgAb interference exists in the presence of naturally occurring human TgAb, our observation may prove to be useful during follow-up of patients with differentiated thyroid cancer. However, further studies are needed to explore the clinical relevance of thyroglobulin antibody levels within or near to the reference range in monitoring these patients.  相似文献   

A microfluidic platform for measuring electrical activity across cells     

Cédric Bathany  Derek L. Beahm  Steve Besch  Frederick Sachs  Susan Z. Hua 《Biomicrofluidics》2012,6(3)

In this paper, we present a microfluidic chip that is capable of measuring electrical conductance through gap junction channels in a 2-dimensional cell sheet. The chip utilizes a tri-stream laminar flow to create a non-conductive sucrose gap between the two conducting solutions so that electrical current can pass across the sucrose gap only through the cells. Using the chip, we tested the effect of a gap junction inhibitor, 2-APB, on the electrical coupling of connexin 43 (Cx43) gap junction channels in NRK-49F cells. We found that 2-APB reversibly blocks the conductivity in a dose-dependent manner. The tri-stream chip further allows us to simultaneously follow the conductance changes and dye diffusion in real time. We show that 2-APB affects both conductance and diffusion, supporting the interpretation that both sets of data reflect the same gap junction activity. The chip provides a generic platform to investigate gap junction properties and to screen drugs that may inhibit or potentiate gap junction transmission.  相似文献   

High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment   总被引：1，自引：0，他引：1  

Rosa P  Tenreiro S  Chu V  Outeiro TF  Conde JP 《Biomicrofluidics》2012,6(1):14109-141099

Microfluidics is an emerging technology which allows the miniaturization, integration, and automation of fluid handling processes. Microfluidic systems offer low sample consumption, significantly reduced processing time, and the prospect of massive parallelization. A microfluidic platform was developed for the control of the soluble cellular microenvironment of Saccharomyces cerevisiae cells, which enabled high-throughput monitoring of the controlled expression of alpha-synuclein (aSyn), a protein involved in Parkinson's disease. Y-shaped structures were fabricated using particle desorption mass spectrometry-based soft-lithography techniques to generate biomolecular gradients along a microchannel. Cell traps integrated along the microchannel allowed the positioning and monitoring of cells in precise locations, where different, well-controlled chemical environments were established. S. cerevisiae cells genetically engineered to encode the fusion protein aSyn-GFP (green fluorescent protein) under the control of GAL1, a galactose inducible promoter, were loaded in the microfluidic structure. A galactose concentration gradient was established in the channel and a time-dependent aSyn-GFP expression was obtained as a function of the positioning of cells along the galactose gradient. Our results demonstrate the applicability of this microfluidic platform to the spatiotemporal control of cellular microenvironment and open a range of possibilities for the study of cellular processes based on single-cell analysis.  相似文献   

Modular microfluidic system as a model of cystic fibrosis airways     

M. Skolimowski  M. Weiss Nielsen  F. Abeille  P. Skafte-Pedersen  D. Sabourin  A. Fercher  D. Papkovsky  S. Molin  R. Taboryski  C. Sternberg  M. Dufva  O. Geschke  J. Emnéus 《Biomicrofluidics》2012,6(3)

A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients.  相似文献   

Right-left digit ratio (2D:4D) and maximal oxygen uptake     

Hill R  Simpson B  Millet G  Manning J  Kilduff L 《Journal of sports sciences》2012,30(2):129-134

A low digit ratio (2D:4D) and low 2D:4D in the right compared with the left hand (right-left 2D:4D) are thought to be determined by high in utero concentrations of testosterone, and are related to "masculine" traits such as aggression and performance in sports like running and rugby. Low right-left 2D:4D is also related to sensitivity to testosterone as measured by the number of cytosine-adenine-guanine triplet repeats in exon 1 of the androgen receptor gene. Here we show that low right-left 2D:4D is associated with high maximal oxygen uptake (VO2(max)), high velocity at VO2(max), and high maximum lactate concentration in a sample of teenage boys. We suggest that low right-left 2D:4D is linked to performance in some sports because it is a proxy of high sensitivity to prenatal and maybe also circulating testosterone and high VO2(max).  相似文献